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Staying on Top of Longevity Research with Instruct

Staying on Top of Longevity Research with Instruct

Hundreds of health studies are published every week. Here's how I use Instruct to find the ones that matter—and turn them into actionable insights in minutes.

By Matt Falconer

Since founding Instruct, many things in my life have taken a backseat. We're on a mission to build a platform that constitutes the future of how people work—a tall order—and naturally one that requires a lot of my time and focus. With that being said, last year I didn't quite get the balance in my life right. I was at the office day and night, and my fitness and health took a low priority. However, as many people do, I set out to use the new year to set that right, and to do it in the most *efficient* way possible.

Instruct produced my running routine, my gym routine—it even plans my meals week to week. However, one thing you should know about me is that I'm hugely into "biohacking". By no means am I anywhere near Bryan Johnson in my approach to it, but I do love to stay up to date with all the health, fitness and longevity studies that come out. Every week, hundreds of interesting studies are published across the world, and I love to stay in the know.

So, I set up an Instruct workflow that each week researches the papers I might've missed, summarises them, distils the insights and presents them to me as an easy-to-read PDF on Friday morning.
I have some pretty strict criteria for this: the studies have to be from trustworthy sources, they have to be peer-reviewed and controlled. Unfortunately, these kinds of studies are written with *very* rich medical terminology. Medical papers love to hide simple ideas behind very serious phrasing. For example:

"A dose-dependent reduction in subjective sleep latency was observed."

Which translates simply to: "People fell asleep faster."

Interestingly, Alfie (my co-founder) and I won Anthropic's last London hackathon with a project called Bulletpapers that helped people understand arXiv papers. This feels like a spiritual continuation of that for me.
What's so special about this is just how quickly I was able to set it up. It genuinely took minutes with the platform, and the vast majority of that time was dedicated to tailoring how and where that digest got delivered. Instruct is able to work 24/7 and starts this process early in the morning, so it's ready by the time I wake up, in my inbox, exactly how I wanted it.

Sometimes I have questions about the papers, and since each workflow run has its own thread, I can just ask the questions there. If I want to see the original study, Instruct will share the PDF with me.

Another thing I love is how adjustable it is. Workflows in Instruct can be endlessly tweaked and tuned—and for me, that looked like adding an ELI5-style section "ELI-NAMR" (Explain Like I'm Not A Medical Researcher) to the top of each breakdown. On a busy Friday, I might just skim these easily digestible summaries until something catches my eye.

In the past few weeks that I've had this live, I've made actionable, conscious health decisions. I've found supplements I may never have come across, exercise techniques that help prevent injuries, and so much more. I've had the ability to discover more research and learn more each day with this Instruct workflow.
If you want to build the same, it's really easy—and I'll help guide you through it. Instruct is a natural language platform, so giving your *instructions* to it as if you were explaining this to another person is best.

Before I build, I typically consider what I want the outcome to be. For me, that was a PDF (I like to save them!) that got shared to my email each week. For you, it might be a Slack digest sent directly to you. Or perhaps, if you're more advanced, you might triage interesting studies relevant to you into a Google Sheet. It's entirely up to you how you tweak and adjust this to work for you.

My initial prompt was:

Every Friday at 9:00 am London time, deliver a 'Weekly Biohacking Breakthroughs' PDF covering the best new research from the past 7 days across six sections: overall longevity, skin/aesthetics, cardiovascular and VO2 max, metabolic/nutrition, cognitive/sleep, and recovery/musculoskeletal/hormonal.

Prioritise peer-reviewed, controlled human studies (especially RCTs) plus strong systematic reviews/meta-analyses; if you include preprints, label them clearly and separate them, and avoid animal/in-vitro studies unless unusually important (and label them).

Use trustworthy sources only (reputable journals, universities, recognised medical organisations), not social media or low-quality blogs. For each study, include the citation, design, sample size/population, intervention vs control, duration/endpoints, and key outcomes with numbers. Add an ELI-NAMR plain-English translation for each study, translating any medical jargon immediately. Include limitations and an Evidence Strength score (1–5).

End each study with an actionable takeaway or 'No action recommended'. Put a one-page Top 10 highlights first, then the sections, email me the PDF, and post brief highlights in chat.

Once you have your prompt ready, creating this workflow in Instruct is straightforward:
1. Open a new chat and describe what you want—just like you'd explain it to a colleague
2. Instruct will start building the workflow and show you what it's doing
3. Test it, refine it, and save it once you're happy with the results

The beauty of working this way is that you're not wrestling with code or complex automation tools. You're just describing what you need in plain language, and Instruct handles the technical complexity behind the scenes.

Beyond biohacking

While I use this for health research, the same approach works for anything you want to stay informed about—industry news, competitor analysis, regulatory updates, or emerging research in your field. The pattern is simple: tell Instruct what information you care about, how you want it processed, and where you want it delivered.
I've seen people use similar workflows to:

  • Monitor patent filings in their industry
  • Track mentions of their company across the web
  • Summarise earnings calls from key companies
  • Curate content for newsletters or social media

⠀The possibilities expand with your imagination, and most users of Instruct tend to think of more and more ideas as they progress.

Your turn

If you're curious about what you could automate with Instruct, I'd encourage you to start simple. Pick one thing you do manually each week that feels repetitive. Describe it to Instruct the way you'd explain it to a smart assistant. See what happens.
The platform is designed for exactly this kind of exploration: no coding required, just clear descriptions of what you need.

Date

January 26, 2026

Written by

Matt Falconer

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